INTRODUCTION: Air pollution in urban areas becomes a severe challenge to nyx 22 brush global health; exposure to polluting gases can lead to different diseases and even human mortality.In this sense, monitoring the concentration of polluting gases such as carbon monoxide and methane is important.OBJECTIVES: This document focuses on developing a Rem
Chimeric antigen receptor T cell (CAR-T) therapy has emerged as a groundbreaking approach in cancer treatment, showcasing remarkable efficacy.However, the formidable challenge lies in taming the formidable side effects associated with this innovative therapy, among which cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity
ABSTRACT Renal calcium oxalate (CaOx) stone is a common urologic disease with a high prevalence and recurrence rate.However, short-chain fatty acids (SCFAs) are less often reported in the prevention of urolithiasis.This study aimed to explore the effect of SCFAs on the renal CaOx stone formation and the underlying mechanisms.Ethylene glycol was use
Background We previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients.All 12 patients received anti-PD-1 systemic therapy before lerapolturev, and 11 of these 12 patients also received anti-PD-1 after lerapolturev.In preclinical models lerapolturev induces intratumoral inna
In humans, killer immunoglobulin-like receptors (KIRs), expressed on natural killer (NK) and thymus-derived (T) cells, and their ligands, primarily the classical class I molecules of the major histocompatibility complex (MHC) expressed on nearly all cells, are both polymorphic.The variation of this receptor-ligand interaction, based on which allele